Purpose of this blog

Dear Reader,

Welcome to the first post of my blog on Industrial Biocatalysis.
In the next few weeks, I plan to regularly post articles on some of the lesser-known facts and aspects of Biocatalysis. The main focus will be on real applications of enzymes.

I tentatively plan to write a series, so come back every now and then!
Topics:

1.      Enzyme flexibility – How many catalysts do you need?
2.      CYP inhibition in metabolism studies – How fundamentally wrong this is!
3.      Lead diversification – How this oversight can cost you money!
4.      Substrate or product instability as limit to enzyme catalysis – How biocatalysis has changed.
5.      Cascade reactions as mimic of whole cell conversions – How to overcome some limitations
6.      Dynamic kinetic resolution of epoxides – How can you have ~30 reactions all lead to ultimately one product?

      Some of the topics can get pretty technical and in those cases, I will provide links to background information. Please provide me with feedback on my posts, but also feel free to suggest topics you want me to write about.

      Cheers,

    

      Erik

     devries.erikjan@gmail.com

      Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture. Christopher K. Savile, Jacob M. Janey, Emily C. Mundorff, Jeffrey C. Moore, Sarena Tam, William R. Jarvis, Jeffrey C. Colbeck, Anke Krebber, Fred J. Fleitz, Jos Brands, Paul N. Devine, Gjalt W. Huisman, Gregory J. Hughes. Published in Science 16 July 2010: 305-309.Published online 17 June 2010 [DOI:10.1126/science.1188934]. Free download after free registration.